Urine Amino Acid Case Study - Eileen Durfee
Urine Amino Acid Case Study — Genetics + HTMA + Custom Transdermal Crèmes
How pairing DNA insights with urine amino acid testing guided two made-to-order crèmes—and moved Eileen from ~50% abnormal markers to a largely normalized profile.
- Serotonin:Dopamine ratio normalized
- NE:Epi ratio strengthened
- L-DOPA capacity restored
- Glycine & Beta-alanine calmed
- Sleep & stress response improved
Why this test mattered
The Metabolic Testing (Urine) reads real-time chemistry—neurotransmitters, amino acids, and stress-hormone metabolites—through an HPA (stress) lens. With Eileen’s dense methylation/detox SNPs, this profile identified the exact co-factors and amino acids to deliver transdermally in day/night crèmes.
HPA summary
- Balanced HPA: decreases pro-inflammatory cytokines.
- Imbalanced HPA: drives inflammation; feedback loops drift.
Custom Transdermal Support AM + PM
AM crème (2×/day, ~30 days): catecholamine precursors/co-factors, active B-vitamins compatible with MTHFR/MTR/MTRR, gentle methyl donors.
PM crème (1×/night, ~55 days): inhibitory tone (GABA focus), histamine balance, sleep repair. Using 2×/night ≈ 30 days for stubborn insomnia.
Before (2022): ~50% abnormal markers
- 5-HT:DA ratio 0.36 (ref 0.49–1.67) — serotonergic tone low vs dopamine.
- NE:Epi ratio 3.30 — fragile sympathetic response.
- L-DOPA 3.90 (16.40–62.30) — limited dopamine synthesis capacity.
- Glycine 3433 (99.5–647.5) & Beta-alanine 121.5 (0.50–38.20) — high one-carbon/pyrimidine turnover demands.
After (2025): ratios normalized, hot spots cooled
- 5-HT:DA ratio 0.68 — in range; mood regulation steadier.
- NE:Epi ratio 6.19 — more resilient stress handling.
- L-DOPA 25.00 — dopamine synthesis capacity restored.
- Glycine 542 (now in range) & Beta-alanine 30.6 — detox “drag” markedly reduced.
- Asn/Ala/Orn/Histamine moved into range; Cystine remains lowish (12.9) → keep sulfur/antioxidant support.
Pathways at a glance
Genetics set the tendencies (COMT/MAO, MTHFR/MTR/MTRR, VDR, GST/NAT). The crèmes were tuned to the urine chemistry so the catecholaminergic/serotonergic, glutamatergic, and trans-methylation/trans-sulfuration pathways could flow instead of bottleneck.
What the profile analyzes
Creatinine; 5-HTP; Serotonin; Dopamine; Serotonin:Dopamine; Epinephrine; Norepinephrine; NE:Epi; 3-Methoxytyramine; L-DOPA; Normetanephrine; Metanephrine; GABA; Glutamic Acid; Histamine; aromatic/branched/essential amino acids (TRP, PHE, TYR, HIS, VAL, LEU, ILE, MET, THR, LYS, Hydroxylysine, PEA); non-essential amino acids (GLN, ASN, ASP, ALA, PRO, ARG, GLY, CYS, SER, Homocysteine, Cystathionine, Hydroxyproline, Homoserine, Homocystine, Cystine); non-proteinogenic (GABA, Beta-alanine, Histamine, Carnosine, Ornithine, Citrulline, Glutathione, Sarcosine, 2-Aminoadipic, Alpha-/Beta-aminobutyric acids).
Collection Essentials
10 AM mid-stream urine; limit protein the night before; avoid nuts, cheese, alcohol; no caffeine morning of.
AM Crème
2×/day (~30 days). Precursors + co-factors aligned to SNPs; gentle methyl donors.
PM Crème
1×/night (~55 days). Inhibitory tone, histamine/sleep support. 2×/night ≈ 30 days if needed.
Policy
Crèmes are made-to-order and non-returnable; no cancellations once compounded.
FAQs
What is Metabolic Testing (Urine)?
A comprehensive urine profile of amino acids, neurotransmitters, and stress metabolites with an HPA focus—used to tailor day/night transdermal crèmes.
How do the crèmes help?
They deliver targeted nutrients through the skin, smoothing kinetics for those with COMT/MAO/GST variants who may react to oral doses.
Who benefits?
Anyone optimizing stress response, inflammation, mood/sleep, detox comfort, or who wants chemistry that matches their genetics/HTMA.
Educational content only; not medical advice. Work with your practitioner for personalized guidance.
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