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Genetic Lab Testing with Consultation
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Genetic Lab Testing with Consultation

SKU 2262
$799.00
3X4 Genetics Blueprint translates key genetic variants into clear, pathway-based health insights—covering 36 metabolic pathways across 6 health categories
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Genetic Lab Testing with Consultation
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3X4 Genetics Blueprint + Eileen Durfee Consultation

If it impacts your health, it belongs in your plan. The 3X4 Genetics Blueprint translates key genetic variants into clear, pathway-based health insights—covering 36 metabolic pathways across 6 health categories—so you can focus on the areas that matter most first.

Your genetics don’t dictate your destiny—but they can reveal where you’re more sensitive and what to prioritize. This report is designed to turn complex genetic data into a smarter, more personal plan for nutrition, lifestyle, training, and recovery.

When you order through Eileen Durfee, you get more than a test—you get support around the whole process so you feel confident from purchase to plan:

  • Help choosing the right testing option for your goals (so you don’t overbuy or under-test)
  • Guidance on what to expect, how to use the report, and how to turn results into priorities
  • A streamlined path to consultation scheduling and next-step planning
  • A practitioner’s lens focused on action: food, lifestyle, training, recovery, and realistic sequencing

What you receive

  • Your pathway impact dashboard (from highest to lowest impact using easy color-coding) so priorities are obvious.
  • Gene results organized by pathway, not dumped as raw data—so patterns appear (inflammation + detox + glucose control, etc.).
  • A framework that connects your results to practical levers: nutrition, lifestyle, training, and recovery.

Why Eileen Durfee’s consultation makes it better

Many genetic reports are informative—but implementation is where people stall. The Blueprint itself emphasizes that the most useful insights emerge when genetic findings are combined with your history, diet, lifestyle, and goals in the hands of an expert practitioner.

With Eileen, you’re not just “reviewing genes.” You’re turning them into a personalized action plan, including:

  • What to address first (highest-impact pathways)
  • What’s likely driving your symptoms or plateaus (cross-pathway patterns)
  • How to tailor food, supplements, stress, sleep, and training to your genetics
  • Clear next steps you can actually follow

Why this approach is superior to typical testing

  • Pathway-level interpretation (systems thinking): you see how genes interact inside real biology, not isolated SNP trivia.
  • Prioritization built in: impact scoring + color-coding prevents overwhelm and guesswork.
  • Practitioner-guided personalization: your results become a strategy, not a PDF that sits in a folder.

How many genes are tested?

137 genes/markers are included.

How these genes connect to pathways in 3X4 Genetics

In the 3X4 Genetics Blueprint, gene variants are organized into pathway-based results (so you’re not left with a disconnected SNP list). The report covers 36 metabolic pathways across 6 health categories, and it calculates an impact level for each pathway using color-coding to show where to focus first.

Below is a practical “gene → pathway” map (the same gene can influence more than one pathway).

Gene explanations by pathway

1) Cellular pathways

A) Methylation (methyl donors, one-carbon cycle, neurotransmitter balance)

Gene(s) Explanation
MTHFR folate activation (methyl cycle throughput)
MTHFD1 folate cycle support (one-carbon metabolism)
MTR remethylates homocysteine to methionine
MTRR regenerates active B12 for MTR
BHMT alternate homocysteine “shortcut” using betaine/choline
CBS diverts homocysteine toward transsulfuration (sulfur pathway)
TCN2 vitamin B12 transport into cells
PEMT endogenous choline/phosphatidylcholine production
CHDH choline → betaine (feeds BHMT methylation)

B) Inflammation (cytokines, acute phase response, immune signaling)

Gene(s) Explanation
TNFA inflammatory signaling intensity
IL-1 inflammatory activation signaling (marker)
IL-6 / IL-6R cytokine signaling and receptor sensitivity
CRP downstream inflammation/acute phase marker
HLA immune recognition; links to gluten/autoimmune susceptibility
PPARA / PPARG / PPARD metabolic inflammation switches (fat/glucose crosstalk)
SIRT1 inflammation control via energy-sensing pathways
FOXO1 / FOXO3 stress-response transcription factors

C) Oxidative stress (antioxidant enzymes, mitochondrial protection)

Gene(s) Explanation
CAT breaks down hydrogen peroxide
MNSOD (SOD2) mitochondrial superoxide defense
GPX1 peroxide neutralization (glutathione system)
NQO1 quinone detox / antioxidant defense
NRF2 master “turn on antioxidant genes” regulator
OGG1 oxidative DNA repair
UCP1 / UCP2 / UCP3 mitochondrial uncoupling; ROS/energy balance

D) Detoxification (Phase I/II detox, clearance, xenobiotics)

Gene(s) Explanation
Phase I (activation/processing)
CYP1A1 / CYP1A2 / CYP1B1 / CYP2C19 / CYP2C9 / CYP2D6 / CYP3A4 drug/hormone/toxin metabolism
EPHX1 epoxide detox (often paired with CYP activity)
ALDH2 aldehyde clearance (alcohol and oxidative byproducts)
Phase II (conjugation/clearance)
GSTM1 / GSTT1 / GSTP1 / GSTO2 glutathione conjugation capacity
NAT1 / NAT2 acetylation (amine/chemical handling)
SULT1A1 sulfation (hormones/phenols)
UGT2B15 / UGT2B17 glucuronidation (hormones/xenobiotics)
PON1 antioxidant/organophosphate handling (cardio + detox overlap)

2) Systems pathways

A) Collagen & joints (connective tissue structure + breakdown/repair)

Gene(s) Explanation
COL1A1 / COL3A1 / COL12A1 collagen structural proteins
GDF5 joint/cartilage development and resilience
MMP1 / MMP2 / MMP3 collagen breakdown/remodeling enzymes
TIMP4 MMP inhibition (controls breakdown)
VEGFA tissue perfusion/healing support (also vascular)

B) Glucose & insulin (glycemic regulation, insulin signaling, storage)

Gene(s) Explanation
TCF7L2 insulin/glucose regulation risk signaling
IRS1 insulin receptor signaling efficiency
SLC2A2 glucose transport (GLUT2)
PPARG / PPARGC1A / PPARA / PPARD insulin sensitivity + fuel switching
FTO appetite/energy balance associations
MTNR1B melatonin receptor; glucose timing/fasting glucose associations
ADIPOQ adiponectin signaling; insulin sensitivity support
LEPR leptin signaling; appetite + metabolic control

C) Memory & brain health (neuroplasticity, vascular brain support, aging risk)

Gene(s) Explanation
APOE lipid transport in brain; cognitive aging associations
TOMM40 mitochondrial import; cognition/aging associations
BDNF neuroplasticity/learning; stress response
COMT dopamine breakdown; cognition/stress tolerance overlap
CACNA1C neuronal calcium signaling
AKT1 neuronal survival/signaling pathways
NOS3/ENOS blood flow support (brain perfusion overlap)

D) Bone health (vitamin D axis + collagen structure)

Gene(s) Explanation
VDR vitamin D receptor function
GC vitamin D binding/transport
CYP2R1 vitamin D activation step
COL1A1 bone matrix collagen backbone

E) Mood & behaviour (serotonin, dopamine, GABA, reward, bonding)

Gene(s) Explanation
Serotonin signaling
5HT2A serotonin receptor signaling (mood, sleep, perception)
HTR1A serotonin receptor regulation (stress/mood)
Dopamine/reward
DRD1 / DRD3 / DRD4 dopamine receptors (motivation/novelty/reward)
ANKK1/DRD2 dopamine D2 pathway marker (reward/addiction tendency)
Breakdown enzymes / neurotransmitter balance
MAOA monoamine breakdown (serotonin/dopamine/norepinephrine)
COMT dopamine/norepinephrine breakdown (stress/cognition)
GAD1 makes GABA (calming neurotransmitter)
GABRA2 GABA receptor signaling (calm/anxiety traits)
Reward, stress buffering, connection
OPRM1 opioid receptor (reward/pain response)
FAAH endocannabinoid breakdown (stress, reward, inflammation overlap)
OXTR oxytocin receptor (bonding/social stress resilience)
ANK3 / CACNA1C neuronal excitability/mood stability markers
CHRNA5 nicotinic receptor (stimulation/addiction tendency)

F) Hormone balance (estrogen/androgen metabolism + binding/clearance)

Gene(s) Explanation
CYP17A1 sex steroid synthesis step
CYP19A1 aromatase (androgen → estrogen)
ESR2 estrogen receptor beta signaling
SHBG hormone binding/availability
SRD5A1 androgen conversion (DHT pathway)
UGT2B15 / UGT2B17 / SULT1A1 hormone clearance (phase II)

G) Histamine overload (breakdown capacity)

Gene(s) Explanation
DAO histamine breakdown in gut/periphery
HNMT histamine breakdown inside cells
(Also influenced by inflammation genes like IL-6/TNFA)

3) Cardiovascular health pathways

A) Vascular health (endothelial function, nitric oxide, repair)

Gene(s) Explanation
NOS3 / ENOS nitric oxide production; vessel flexibility
VEGF / VEGFA / VEGFR2 vascular growth/repair signaling
HO-1 (HMOX1) oxidative/inflammatory vessel protection
CRP / OGG1 / NRF2 inflammation/oxidative stress impacts vessels

B) Blood pressure (RAAS signaling + adrenergic tone)

Gene(s) Explanation
ACE / ACE2 angiotensin processing balance
AGT angiotensinogen supply
AGTR1 / AGTR2 angiotensin receptor signaling
REN renin initiation of RAAS cascade
ADRB2 adrenergic tone (stress response, vascular constriction/dilation)

C) Blood clotting (coagulation risk tendency)

Gene(s) Explanation
F2 prothrombin pathway
F5 Factor V clotting regulation
HPA-1 platelet adhesion marker

D) Cholesterol & lipids (transport, triglycerides, HDL dynamics)

Gene(s) Explanation
APOE lipoprotein transport/clearance
APOA5 / APOC3 triglyceride handling
APOA2 fat response signaling (diet-fat sensitivity traits)
CETP HDL/LDL particle exchange
LPL triglyceride breakdown from particles
FABP2 intestinal fat absorption/handling
PON1 HDL antioxidant function

4) Energy pathways (fat storage, release, appetite, metabolism)

A) Pro-inflammatory fat

Gene(s) Explanation
TNFA / IL-1 / IL-6 / IL-6R / CRP adipose inflammation signaling
ADIPOQ anti-inflammatory adipokine support
PPARG / PPARA / SIRT1 inflammation ↔ metabolism switches

B) Adipogenesis (fat-cell creation/storage propensity)

Gene(s) Explanation
PPARG adipocyte differentiation “master switch”
PLIN fat droplet storage dynamics
ADRB3 / ADRB2 fat mobilization signaling
LEPR leptin feedback (storage vs burn)
MMP2 tissue remodeling that can affect adipose expansion

C) Weight gain & weight loss resistance

Gene(s) Explanation
FTO weight regulation associations
MC4R appetite/satiety control center signaling
CLOCK circadian rhythm ↔ metabolism coupling
UCP1/2/3 energy expenditure/thermogenesis tendency
TCF7L2 / IRS1 glucose signaling that affects storage patterns

D) Exercise response & energy expenditure

Gene(s) Explanation
PPARGC1A / PPARD / PPARA mitochondrial biogenesis & fuel switching
ADRB2 / ADRB3 fat mobilization during activity
UCP genes resting burn/thermogenesis traits

E) Appetite / satiety / intake

Gene(s) Explanation
LEPR / MC4R / FTO hunger/fullness signaling balance
TAS2R38 bitter taste sensitivity (food preference effects)

5) Activity pathways (training, performance, injury risk)

A) Injury / connective tissue recovery

Gene(s) Explanation
COL1A1 / COL3A1 / COL12A1 / GDF5 tissue strength
MMP3 / TIMP4 remodeling balance
VEGFA healing blood supply support
TNFA / CRP inflammation that can impair recovery

B) Endurance / oxygen utilization

Gene(s) Explanation
ACE endurance vs power tendency marker
HIF1A oxygen response signaling
NOS3 blood flow support
VEGF capillary growth signaling
PPARGC1A / PPARA aerobic capacity support pathways

C) Power / sprint traits

Gene(s) Explanation
ACTN3 fast-twitch muscle performance marker
CKM muscle energy buffering
AMPD1 ATP recycling during intense bursts

D) Training response (adaptation rate)

Gene(s) Explanation
ACE / ACTN3 / PPARGC1A / NRF2 adaptation, recovery, oxidative load handling
ACSL1 fatty acid activation for energy use in muscle

6) Nutrients pathways (absorption, activation, utilization)

A) Vitamin B12

Gene(s) Explanation
TCN2 transport into cells
FUT2 gut/secretor status; influences B12 availability via microbiome dynamics

B) Choline

Gene(s) Explanation
PEMT / CHDH / BHMT choline need & use in methylation/membranes

C) Folate

Gene(s) Explanation
MTHFR / MTHFD1 folate processing and availability

D) Salt sensitivity

Gene(s) Explanation
ACE / AGT / AGTR1 / REN RAAS control of fluid and pressure

E) Vitamin D

Gene(s) Explanation
VDR receptor response
GC transport protein
CYP2R1 activation step

F) Caffeine

Gene(s) Explanation
CYP1A2 primary caffeine metabolism speed
COMT stimulant sensitivity via catechol handling

G) Fatty acids

Gene(s) Explanation
FADS1 / FADS2 omega-3/omega-6 conversion efficiency
ELOVL2 long-chain fatty acid elongation
APOA2 / APOA5 / FABP2 dietary fat response/handling

H) Gluten

Gene(s) Explanation
HLA celiac-associated immune recognition markers

I) Iron overload

Gene(s) Explanation
HFE iron absorption regulation

J) Vitamin C

Gene(s) Explanation
SLC23A1 vitamin C transport into cells

FAQ — Genetic Lab Testing with Consultation (3X4 Genetics Blueprint)

1. What is this product?

It’s Genetic Lab Testing with Consultation, built around the 3X4 Genetics Blueprint, which translates key genetic variants into pathway-based health insights across 36 metabolic pathways in 6 health categories.

2. What’s included with the purchase?

You receive a pathway impact dashboard ranked from highest to lowest impact with easy color-coding, gene results organized by pathway (instead of raw data) to help patterns show up, and a framework connecting results to practical levers like nutrition, lifestyle, training, and recovery.

3. What will Eileen help you do during the consultation?

The consultation is focused on turning gene insights into a personalized action plan, including what to address first (highest-impact pathways), what they are driving symptoms or plateaus (cross-pathway patterns), how to tailor food, supplements, stress, sleep, and training to your genetics, and clear, followable next steps.

4. How is this different from “typical” genetic testing reports?

This approach emphasizes pathway-level interpretation (systems thinking) rather than isolated SNPs, built-in prioritization via impact scoring and color-coding, and practitioner-guided personalization so results become a strategy (not just a report).

5. How many genes/markers are included?

The page states 137 genes/markers are included.

6. How are results organized in the report?

Gene variants are organized into pathway-based results, and an impact level is calculated for each pathway using color-coding to show where to focus first.

7. What are the main health categories/pathway groups covered?

The report covers 36 metabolic pathways across 6 health categories, organized into pathway groups like Cellular pathways, Systems pathways, Cardiovascular health pathways, Energy pathways, Activity pathways, and Nutrients pathways.

8. What “cellular pathways” are included?

Methylation, inflammation, oxidative stress, and detoxification (Phase I & Phase II).

9. What “systems pathways” are included?

Collagen & joints, glucose & insulin, memory & brain health, bone health, mood & behaviour, hormone balance, and histamine overload.

10. What cardiovascular pathways are included?

Vascular health, blood pressure, blood clotting, and cholesterol & lipids.

11. What energy-related pathways are included?

Pro-inflammatory fat, adipogenesis, weight gain & weight loss resistance, exercise response & energy expenditure, and appetite / satiety / intake.

12. What activity/training pathways are included?

Injury / connective tissue recovery, endurance / oxygen utilization, power / sprint traits, and training response (adaptation rate).

13. What nutrient-related pathways are included?

Vitamin B12, Choline, Folate, Salt sensitivity, Vitamin D, Caffeine, Fatty acids, Gluten, Iron overload, and Vitamin C.

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