If it impacts your health, it belongs in your plan. The 3X4 Genetics Blueprint translates key genetic variants into clear, pathway-based health insights—covering 36 metabolic pathways across 6 health categories—so you can focus on the areas that matter most first.
Your genetics don’t dictate your destiny—but they can reveal where you’re more sensitive and what to prioritize. This report is designed to turn complex genetic data into a smarter, more personal plan for nutrition, lifestyle, training, and recovery.
When you order through Eileen Durfee, you get more than a test—you get support around the whole process so you feel confident from purchase to plan:
Many genetic reports are informative—but implementation is where people stall. The Blueprint itself emphasizes that the most useful insights emerge when genetic findings are combined with your history, diet, lifestyle, and goals in the hands of an expert practitioner.
With Eileen, you’re not just “reviewing genes.” You’re turning them into a personalized action plan, including:
137 genes/markers are included.
In the 3X4 Genetics Blueprint, gene variants are organized into pathway-based results (so you’re not left with a disconnected SNP list). The report covers 36 metabolic pathways across 6 health categories, and it calculates an impact level for each pathway using color-coding to show where to focus first.
Below is a practical “gene → pathway” map (the same gene can influence more than one pathway).
| Gene(s) | Explanation |
|---|---|
| MTHFR | folate activation (methyl cycle throughput) |
| MTHFD1 | folate cycle support (one-carbon metabolism) |
| MTR | remethylates homocysteine to methionine |
| MTRR | regenerates active B12 for MTR |
| BHMT | alternate homocysteine “shortcut” using betaine/choline |
| CBS | diverts homocysteine toward transsulfuration (sulfur pathway) |
| TCN2 | vitamin B12 transport into cells |
| PEMT | endogenous choline/phosphatidylcholine production |
| CHDH | choline → betaine (feeds BHMT methylation) |
| Gene(s) | Explanation |
|---|---|
| TNFA | inflammatory signaling intensity |
| IL-1 | inflammatory activation signaling (marker) |
| IL-6 / IL-6R | cytokine signaling and receptor sensitivity |
| CRP | downstream inflammation/acute phase marker |
| HLA | immune recognition; links to gluten/autoimmune susceptibility |
| PPARA / PPARG / PPARD | metabolic inflammation switches (fat/glucose crosstalk) |
| SIRT1 | inflammation control via energy-sensing pathways |
| FOXO1 / FOXO3 | stress-response transcription factors |
| Gene(s) | Explanation |
|---|---|
| CAT | breaks down hydrogen peroxide |
| MNSOD (SOD2) | mitochondrial superoxide defense |
| GPX1 | peroxide neutralization (glutathione system) |
| NQO1 | quinone detox / antioxidant defense |
| NRF2 | master “turn on antioxidant genes” regulator |
| OGG1 | oxidative DNA repair |
| UCP1 / UCP2 / UCP3 | mitochondrial uncoupling; ROS/energy balance |
| Gene(s) | Explanation |
|---|---|
| Phase I (activation/processing) | |
| CYP1A1 / CYP1A2 / CYP1B1 / CYP2C19 / CYP2C9 / CYP2D6 / CYP3A4 | drug/hormone/toxin metabolism |
| EPHX1 | epoxide detox (often paired with CYP activity) |
| ALDH2 | aldehyde clearance (alcohol and oxidative byproducts) |
| Phase II (conjugation/clearance) | |
| GSTM1 / GSTT1 / GSTP1 / GSTO2 | glutathione conjugation capacity |
| NAT1 / NAT2 | acetylation (amine/chemical handling) |
| SULT1A1 | sulfation (hormones/phenols) |
| UGT2B15 / UGT2B17 | glucuronidation (hormones/xenobiotics) |
| PON1 | antioxidant/organophosphate handling (cardio + detox overlap) |
| Gene(s) | Explanation |
|---|---|
| COL1A1 / COL3A1 / COL12A1 | collagen structural proteins |
| GDF5 | joint/cartilage development and resilience |
| MMP1 / MMP2 / MMP3 | collagen breakdown/remodeling enzymes |
| TIMP4 | MMP inhibition (controls breakdown) |
| VEGFA | tissue perfusion/healing support (also vascular) |
| Gene(s) | Explanation |
|---|---|
| TCF7L2 | insulin/glucose regulation risk signaling |
| IRS1 | insulin receptor signaling efficiency |
| SLC2A2 | glucose transport (GLUT2) |
| PPARG / PPARGC1A / PPARA / PPARD | insulin sensitivity + fuel switching |
| FTO | appetite/energy balance associations |
| MTNR1B | melatonin receptor; glucose timing/fasting glucose associations |
| ADIPOQ | adiponectin signaling; insulin sensitivity support |
| LEPR | leptin signaling; appetite + metabolic control |
| Gene(s) | Explanation |
|---|---|
| APOE | lipid transport in brain; cognitive aging associations |
| TOMM40 | mitochondrial import; cognition/aging associations |
| BDNF | neuroplasticity/learning; stress response |
| COMT | dopamine breakdown; cognition/stress tolerance overlap |
| CACNA1C | neuronal calcium signaling |
| AKT1 | neuronal survival/signaling pathways |
| NOS3/ENOS | blood flow support (brain perfusion overlap) |
| Gene(s) | Explanation |
|---|---|
| VDR | vitamin D receptor function |
| GC | vitamin D binding/transport |
| CYP2R1 | vitamin D activation step |
| COL1A1 | bone matrix collagen backbone |
| Gene(s) | Explanation |
|---|---|
| Serotonin signaling | |
| 5HT2A | serotonin receptor signaling (mood, sleep, perception) |
| HTR1A | serotonin receptor regulation (stress/mood) |
| Dopamine/reward | |
| DRD1 / DRD3 / DRD4 | dopamine receptors (motivation/novelty/reward) |
| ANKK1/DRD2 | dopamine D2 pathway marker (reward/addiction tendency) |
| Breakdown enzymes / neurotransmitter balance | |
| MAOA | monoamine breakdown (serotonin/dopamine/norepinephrine) |
| COMT | dopamine/norepinephrine breakdown (stress/cognition) |
| GAD1 | makes GABA (calming neurotransmitter) |
| GABRA2 | GABA receptor signaling (calm/anxiety traits) |
| Reward, stress buffering, connection | |
| OPRM1 | opioid receptor (reward/pain response) |
| FAAH | endocannabinoid breakdown (stress, reward, inflammation overlap) |
| OXTR | oxytocin receptor (bonding/social stress resilience) |
| ANK3 / CACNA1C | neuronal excitability/mood stability markers |
| CHRNA5 | nicotinic receptor (stimulation/addiction tendency) |
| Gene(s) | Explanation |
|---|---|
| CYP17A1 | sex steroid synthesis step |
| CYP19A1 | aromatase (androgen → estrogen) |
| ESR2 | estrogen receptor beta signaling |
| SHBG | hormone binding/availability |
| SRD5A1 | androgen conversion (DHT pathway) |
| UGT2B15 / UGT2B17 / SULT1A1 | hormone clearance (phase II) |
| Gene(s) | Explanation |
|---|---|
| DAO | histamine breakdown in gut/periphery |
| HNMT | histamine breakdown inside cells |
| (Also influenced by inflammation genes like IL-6/TNFA) | |
| Gene(s) | Explanation |
|---|---|
| NOS3 / ENOS | nitric oxide production; vessel flexibility |
| VEGF / VEGFA / VEGFR2 | vascular growth/repair signaling |
| HO-1 (HMOX1) | oxidative/inflammatory vessel protection |
| CRP / OGG1 / NRF2 | inflammation/oxidative stress impacts vessels |
| Gene(s) | Explanation |
|---|---|
| ACE / ACE2 | angiotensin processing balance |
| AGT | angiotensinogen supply |
| AGTR1 / AGTR2 | angiotensin receptor signaling |
| REN | renin initiation of RAAS cascade |
| ADRB2 | adrenergic tone (stress response, vascular constriction/dilation) |
| Gene(s) | Explanation |
|---|---|
| F2 | prothrombin pathway |
| F5 | Factor V clotting regulation |
| HPA-1 | platelet adhesion marker |
| Gene(s) | Explanation |
|---|---|
| APOE | lipoprotein transport/clearance |
| APOA5 / APOC3 | triglyceride handling |
| APOA2 | fat response signaling (diet-fat sensitivity traits) |
| CETP | HDL/LDL particle exchange |
| LPL | triglyceride breakdown from particles |
| FABP2 | intestinal fat absorption/handling |
| PON1 | HDL antioxidant function |
| Gene(s) | Explanation |
|---|---|
| TNFA / IL-1 / IL-6 / IL-6R / CRP | adipose inflammation signaling |
| ADIPOQ | anti-inflammatory adipokine support |
| PPARG / PPARA / SIRT1 | inflammation ↔ metabolism switches |
| Gene(s) | Explanation |
|---|---|
| PPARG | adipocyte differentiation “master switch” |
| PLIN | fat droplet storage dynamics |
| ADRB3 / ADRB2 | fat mobilization signaling |
| LEPR | leptin feedback (storage vs burn) |
| MMP2 | tissue remodeling that can affect adipose expansion |
| Gene(s) | Explanation |
|---|---|
| FTO | weight regulation associations |
| MC4R | appetite/satiety control center signaling |
| CLOCK | circadian rhythm ↔ metabolism coupling |
| UCP1/2/3 | energy expenditure/thermogenesis tendency |
| TCF7L2 / IRS1 | glucose signaling that affects storage patterns |
| Gene(s) | Explanation |
|---|---|
| PPARGC1A / PPARD / PPARA | mitochondrial biogenesis & fuel switching |
| ADRB2 / ADRB3 | fat mobilization during activity |
| UCP genes | resting burn/thermogenesis traits |
| Gene(s) | Explanation |
|---|---|
| LEPR / MC4R / FTO | hunger/fullness signaling balance |
| TAS2R38 | bitter taste sensitivity (food preference effects) |
| Gene(s) | Explanation |
|---|---|
| COL1A1 / COL3A1 / COL12A1 / GDF5 | tissue strength |
| MMP3 / TIMP4 | remodeling balance |
| VEGFA | healing blood supply support |
| TNFA / CRP | inflammation that can impair recovery |
| Gene(s) | Explanation |
|---|---|
| ACE | endurance vs power tendency marker |
| HIF1A | oxygen response signaling |
| NOS3 | blood flow support |
| VEGF | capillary growth signaling |
| PPARGC1A / PPARA | aerobic capacity support pathways |
| Gene(s) | Explanation |
|---|---|
| ACTN3 | fast-twitch muscle performance marker |
| CKM | muscle energy buffering |
| AMPD1 | ATP recycling during intense bursts |
| Gene(s) | Explanation |
|---|---|
| ACE / ACTN3 / PPARGC1A / NRF2 | adaptation, recovery, oxidative load handling |
| ACSL1 | fatty acid activation for energy use in muscle |
| Gene(s) | Explanation |
|---|---|
| TCN2 | transport into cells |
| FUT2 | gut/secretor status; influences B12 availability via microbiome dynamics |
| Gene(s) | Explanation |
|---|---|
| PEMT / CHDH / BHMT | choline need & use in methylation/membranes |
| Gene(s) | Explanation |
|---|---|
| MTHFR / MTHFD1 | folate processing and availability |
| Gene(s) | Explanation |
|---|---|
| ACE / AGT / AGTR1 / REN | RAAS control of fluid and pressure |
| Gene(s) | Explanation |
|---|---|
| VDR | receptor response |
| GC | transport protein |
| CYP2R1 | activation step |
| Gene(s) | Explanation |
|---|---|
| CYP1A2 | primary caffeine metabolism speed |
| COMT | stimulant sensitivity via catechol handling |
| Gene(s) | Explanation |
|---|---|
| FADS1 / FADS2 | omega-3/omega-6 conversion efficiency |
| ELOVL2 | long-chain fatty acid elongation |
| APOA2 / APOA5 / FABP2 | dietary fat response/handling |
| Gene(s) | Explanation |
|---|---|
| HLA | celiac-associated immune recognition markers |
| Gene(s) | Explanation |
|---|---|
| HFE | iron absorption regulation |
| Gene(s) | Explanation |
|---|---|
| SLC23A1 | vitamin C transport into cells |
It’s Genetic Lab Testing with Consultation, built around the 3X4 Genetics Blueprint, which translates key genetic variants into pathway-based health insights across 36 metabolic pathways in 6 health categories.
You receive a pathway impact dashboard ranked from highest to lowest impact with easy color-coding, gene results organized by pathway (instead of raw data) to help patterns show up, and a framework connecting results to practical levers like nutrition, lifestyle, training, and recovery.
The consultation is focused on turning gene insights into a personalized action plan, including what to address first (highest-impact pathways), what they are driving symptoms or plateaus (cross-pathway patterns), how to tailor food, supplements, stress, sleep, and training to your genetics, and clear, followable next steps.
This approach emphasizes pathway-level interpretation (systems thinking) rather than isolated SNPs, built-in prioritization via impact scoring and color-coding, and practitioner-guided personalization so results become a strategy (not just a report).
The page states 137 genes/markers are included.
Gene variants are organized into pathway-based results, and an impact level is calculated for each pathway using color-coding to show where to focus first.
The report covers 36 metabolic pathways across 6 health categories, organized into pathway groups like Cellular pathways, Systems pathways, Cardiovascular health pathways, Energy pathways, Activity pathways, and Nutrients pathways.
Methylation, inflammation, oxidative stress, and detoxification (Phase I & Phase II).
Collagen & joints, glucose & insulin, memory & brain health, bone health, mood & behaviour, hormone balance, and histamine overload.
Vascular health, blood pressure, blood clotting, and cholesterol & lipids.
Pro-inflammatory fat, adipogenesis, weight gain & weight loss resistance, exercise response & energy expenditure, and appetite / satiety / intake.
Injury / connective tissue recovery, endurance / oxygen utilization, power / sprint traits, and training response (adaptation rate).
Vitamin B12, Choline, Folate, Salt sensitivity, Vitamin D, Caffeine, Fatty acids, Gluten, Iron overload, and Vitamin C.
