Natural GH support for recovery, sleep, lean mass, and healthy aging

Sermorelin is a growth hormone–releasing hormone (GHRH) analog that encourages your body to release more of its own growth hormone in a natural, pulsatile pattern. Instead of supplying HGH directly, it supports the GH/IGF-1 pathway through your pituitary—making it a popular option for fat loss, recovery, and longevity support with a more physiologic approach.

Key Benefits

• Supports lean muscle retention and improved recovery from training
• Helps promote fat metabolism (especially when paired with resistance training and sleep)
• Encourages deeper, more restorative sleep (where natural GH pulses occur)
• Supports collagen and connective tissue health (skin, joints, tendons)
• Often favored for sustainable, long-term wellness protocols

How It Works

Sermorelin mimics the active portion of GHRH (1–29), binding receptors in the pituitary to trigger pulses of growth hormone, which can then support IGF-1 production—all while keeping your body’s feedback mechanisms intact.

Typical Dosage & Administration (Informational)

• Beginner starting dose: 200–300 mcg nightly
• Typical range: 200–500 mcg per day
• Timing: 30–60 minutes before bed, ideally fasted (avoid eating for ~1 hour before/after when possible)
• Administration: subcutaneous injection (abdomen or thigh; rotate sites)

Cycle Length (Common Use Pattern)

• 8–12 weeks is a common starting cycle
• Many users take a 2–4 week break or reassess before repeating

How to Pair Sermorelin with Other Peptides

Pairing is usually based on goal:

For stronger GH pulses (sleep/fat loss/recovery):

• Add Ipamorelin (often used because it stimulates GH through a different pathway).
  Stack logic: Sermorelin = GHRH signal, Ipamorelin = GHRP pathway.

For injury support while using GH pathways:

• Add BPC-157 for tendon/ligament/joint and gut lining support without adding extra GH-axis stimulation.
  Typical informational range: 250–500 mcg daily subQ (often near the area of concern).

Safety Notes

• Generally well tolerated; common mild effects can include injection-site irritation, temporary flushing, headache, or short-term sleep adjustment.
• Higher doses don’t necessarily mean better results and can increase side effects.
• Avoid use without clinician approval if pregnant/nursing, under 18, or if you have a hormone-sensitive condition or active cancer history.

Legal & Testing Note

Sermorelin is typically available by prescription/compounding through clinics in many settings; tested athletes should assume GH-axis peptides may be restricted/prohibited under anti-doping rules.

Bottom line: Sermorelin is a nightly injectable designed to support natural GH pulses—a solid choice for beginners focused on sleep quality, recovery, body composition, and healthy aging, especially when used consistently and paired with smart training and nutrition.

Overview (Research Context)

In research literature, sermorelin (GHRH 1–29) is commonly discussed as a GHRH-pathway peptide used to explore receptor-mediated signaling and downstream endocrine mechanisms in controlled experimental models. It may be used by qualified researchers when studying hypothalamic-pituitary signaling and related biological pathways.

Key Product Details

• Net Content: 5mg per vial
• Form: Lyophilized (freeze-dried) powder
• Molecular Formula: C149H246N44O42S
• Molecular Weight: 3357.933 g/mol
• PubChem CID: 16129620

Peptide Sequence

Tyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL-Phe-DL-xiThr-DL-Asn-DL-Ser-DL-Tyr-DL-Arg-DL-Lys-DL-Val-DL-Leu-Gly-DL-Gln-DL-Leu-DL-Ser-DL-Ala-DL-Arg-DL-Lys-DL-Leu-DL-Leu-DL-Gln-DL-Asp-DL-xiIle-DL-Met-DL-Ser-DL-Arg

Storage & Handling

• Shipping stability: Lyophilized products are designed to remain stable for shipping for up to approximately 3–4 months.
• After reconstitution: Once reconstituted (e.g., with bacteriostatic water), store refrigerated. Post-reconstitution stability is typically described as up to 30 days when kept cold.
• General guidance: Keep vials cold and protected from light upon receipt.
• Short-term storage: Refrigeration at about <4°C (39°F) is generally suitable when using within days to months.
• Long-term storage: For extended storage (months to years), freezing around -80°C (-112°F) is preferred to preserve stability.

Research Use Only (RUO) Disclaimer

For Research Use Only (RUO). Not for human consumption.

This product is provided solely for in-vitro studies. It is not a medicine or drug and is not approved to diagnose, prevent, treat, or cure any disease. Bodily introduction into humans or animals is strictly prohibited.

Suggested “Resources”

• Bagno LL et al. Growth Hormone–Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy. J Am Heart Assoc. 2015.
• Kanashiro-Takeuchi RM et al. Targeting growth hormone-releasing hormone receptor in heart failure due to myocardial infarction. Oncotarget. 2015.
• Tang S et al. Interactions between GHRH and GABAARs in epilepsy patients and animal models. Sci Rep. 2017.
• Shepherd BS et al. Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout. Comp Biochem Physiol A. 2007.
• Walker RF. Sermorelin: A better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006.
• Wahid ST et al. Partial tachyphylaxis to somatostatin analogues in acromegaly. Eur J Endocrinol. 2002.