GHK-Cu (50 mg) — Copper Peptide Research Vial

Overview

In preclinical research contexts, GHK-Cu is investigated for its relationship to collagen-associated pathways, gene-expression regulation, and antioxidant enzyme signaling linked to copper-mediated redox biology. It is also used as a model compound to evaluate peptide-driven tissue remodeling, metalloprotein regulation, and regenerative biochemistry in vitro and in vivo (animal models).

Product Details

• Product: GHK-Cu (Copper Peptide) — Research Use Only
• Quantity: 50 mg per vial
• Form: Lyophilized (powder) form for maximum stability during storage and shipping

Overview (Research Context)

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a low-molecular-weight copper-binding peptide reported in biological fluids and extracellular matrices. Its high affinity for divalent copper makes it a useful research tool for exploring copper-dependent biochemical processes and signaling networks in fibroblast, endothelial, immune-cell, and neuronal experimental systems.

Biochemical Characteristics

The histidine imidazole ring and terminal amine groups in GHK coordinate Cu²⁺ to form a stable complex suitable for controlled laboratory workflows. This chelation is often discussed in research settings for helping maintain copper in a regulated state during experimental assays.

• Peptide Sequence: Gly-His-Lys (Cu²⁺)
• Molecular Formula: C₁₄H₂₃CuN₆O₄
• Molecular Weight: 401.91 g/mol
• PubChem CID: 73587
• CAS Number: 89030-95-5

Research Applications

GHK-Cu is utilized in laboratory research to investigate pathways and biomarkers associated with:

• Fibroblast migration and extracellular matrix synthesis models
• Angiogenic signaling in endothelial cell assays
• Immune-cell recruitment and inflammatory mediator modulation (preclinical models)
• Oxidative stress response signaling and redox-balance assays
• Neuronal tissue and regeneration-related experimental systems
• Antimicrobial interaction studies and transcriptional response profiling

Pathway / Mechanistic Research Themes

Mechanistic investigations commonly explore GHK-Cu in the context of multi-pathway signaling, including research discussions around integrin-linked signaling, TGF-β-associated regulation, modulation of pro-inflammatory cytokine signaling, and activation of antioxidant response elements. Gene-expression datasets in preclinical literature describe transcriptional influence across networks involved in cellular migration, extracellular matrix turnover, neuronal survival, and redox regulation.

Preclinical Research Summary

Published experimental work includes in-vitro fibroblast/keratinocyte systems, endothelial assays, neuronal model studies, antimicrobial interaction testing, and in-vivo animal models of tissue injury and inflammation. Reported observations include changes in cellular migration, extracellular matrix deposition, inflammatory mediator profiles, and gene-expression patterns linked to regeneration and stress-response biology. All discussion is presented strictly within laboratory research contexts.

Form & Analytical Testing

Supplied as a synthetic research-grade peptide complex in lyophilized powder form. Product identity and purity are commonly confirmed using analytical methods such as HPLC and mass spectrometry (MS). Batch documentation may be available depending on your procurement workflow.

References

• Pickart L. et al., Biochimica et Biophysica Acta (2015) 1850(8):1863–1885
• Maquart F.X. et al., FEBS Letters (1988) 238(2):343–346
• Siméon A. et al., Journal of Investigative Dermatology (2000) 115(6):961–968